23andMe and AncestryDNA provide different but consistent data

A new preprint at Biorxiv reports a comparison between DNA testing results from companies 23andMe, AncestryDNA, and Gencove.

In February 2019, one individual sent identical saliva samples to the two most popular DNA testing services, and to the low-coverage whole-genome sequencing company. Received results were compared on a level of raw genetic data – single nucleotide polymorphisms.

Mere 12.9% of SNPs were common for both 23andMe and AncestryDNA. This observation suggests that, although companies aim to inform about ancestry and health, they test different genomic places in 87.1%.

SNPs shared between both services were highly consistent – identical in 99.6% – which proves the high quality of used SNP arrays.

The analysis underscores the highly experimental status of current low-coverage services, such as Gencove. In contrast to almost 100% consistency of SNP arrays, data from Gencove were assessed to be consistent with other services in only 72.3% of SNPs.

It should be noted that data are based on a single individual of unknown ethnicity, and all services are certainly changing in time.

Preprint: Prag Batra, Kuan-lin Huang (2019). A Genotype Concordance Study between Consumer Genetic Testing Services. Doi:10.1101/795666.
Photo: Nicole Leidholm, USAF

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