All current approaches to CRISPR delivery rely on invasive procedures, such as injections into specific organs. The most convenient way…
Discoveries
A study of nearly 4 thousand individuals with ADHD and disruptive behaviors has found new variants contributing to the risk…
Genetic modifications are often used to verify the mechanisms of drugs. To a surprise of scientists, 10 cancer drugs miss…
Not all mutations are equal – this sentence sounds obvious, but biological reality offers surprisingly complex mechanisms behind it. Two…
In plant genomes, histone H1 and DNA methylation cooperatively silence transposable elements, silence intragenic antisense transcripts, as well as maintain…
UBE3A encodes E3 ubiquitin ligase and regulates brain’s immune system, which is associated with Angelman syndrome. More: UBE3A regulates the…
Novel rare neurodevelopmental disorder manifests itself by speech delay, intellectual disability, dysmorphic facial features, abnormal MRI, hypotonia – and it’s…
Polygenic risk score connects many genetic variants to determine the risk of a disease – in the case of obesity,…
Out of 295 yeast strains, each with deleted single intron, 64% do not survive stress conditions. Their function in stress…
Enhancer specific for cell type helps to form pre-initiation complex – in a manner of burst frequency, stimulates expression of…