More: A stress response that allows highly mutated eukaryotic cells to survive and proliferate, R. A. Zabinsky et al., posted at bioRxiv 9th January 2019,…
Novel method for detection of cancer driver mutations
A new method of cancer genome analysis have led to identification of rare mutations contributing to cancer development. The main challenge of cancer genomics is…
PCF11 is a critical regulator of neuroblastoma
PCF11 gene regulates many pathways in neuroblastoma tissues by a process called alternative polyadenylation (APA). Brain tumors of infants and children are the most common…
Liver cancer gains new immunotherapeutic biopharmaceutical: pembrolizumab
Pembrolizumab, previously approved for various types of cancer diseases, has been approved for use in patients with hepatocellular carcinoma. Immunotherapies thrive in research initiatives and…
oncRNA proposed – new molecules driving cancer
A new class of cancer-specific molecules has been identified and named as orphan noncoding RNA. Acronim oncRNA also relates them to potential oncogenic role. A…
H3F3A mutations can be detected in bloodstream
Pediatric patients with diffuse midline gliomas have acquired a new tool: non-invasive liquid biopsy detecting essential variantions of H3F3A gene. Histone genes (HIST1H3B/C, HIST2H3C, H3F3A)…
BRAF-V600E mutations underlie long-term epilepsy-associated tumors (LEAT)
Approximately half of brain cancer diseases with epilepsy symptoms may be associated with mutations in BRAF-V600E gene. A study found that 50% of 56 patients…
Mutations leading to cancer can be detected even 10 years before disease
Broad study of 2,658 patients, involving 39 types of cancer, has described mutations landscape. Cancer diseases on every stage are inevitably associated with genome mutations.…
The largest catalogue of cancer mutations – COSMIC
A new version of COSMIC (Catalogue Of Somatic Mutations In Cancer) is available under https://cancer.sanger.ac.uk/cosmic. 2018 v86 relase of the catalogue describes 719 genes in…
PRDM9 drives genomic instability in cancer
Gene PRDM9 have been associated with 32 various cancer types. One of the main hallmarks of cancer diseases is genome instability. It is global state…