Guidance of drug discovery might be possible with PheWAS
PheWAS – Phenome Wide Association Studies – have been tested within group of 697,815 individuals described by extensive health data, including genome sequence.
PheWAS may assist drug discovery by revealing details of genetic variants associated with wide group of patients treated for a specific disease. Changes in the genome can be also exploited to provide better use of existing drugs.
Potential utility of the method was tested on four genomic databases. The analysis replicated 75% of previous findings. In addition, nine new mutations were associated with clinical outcomes and may be directly targeted in future therapeutic approaches.
More: “Phenome-wide association studies across large population cohorts support drug target validation”, D. Diogo et al., 2018, doi:10.1038/s41467-018-06540-3.