More: Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline, H. A. Grunwald et al., published 23rd January 2019, doi:10.1038/s41586-019-0875-2
Plant genome: new insights into methylation mechanisms
More: DNA methylation and histone H1 cooperatively repress transposable elements and aberrant intragenic transcripts, J. Choi et al., posted 27th January 2019 at bioRxiv, doi:10.1101/527523…
The future of genomics – predictions of 24 experts
More: Where is genomics going next? B. Cheifet, with: R. Knight, M. Zavolan, S. Yup Lee, H. Ma, J. Ule, O. Harismendy, J. Bhak, N.…
A new, essential function of introns in eukaryotic cells: stress response
More: Introns are mediators of cell response to starvation, J. Parenteau et al., published 16th January 2019, doi:10.1038/s41586-018-0859-7 Excised linear introns regulate growth in yeast,…
Critique of recent polygenic risk scores
More: The illusion of polygenic disease risk prediction, N. J. Wald & R. Old, published 12th January 2019, doi:10.1038/s41436-018-0418-5
“Camouflaged genes” – a challenge in human genome sequencing
More: Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight, M. T. W. Ebbert et al., posted at bioRxiv 9th January…
Genomics England sequenced 100,000 genomes in five years
The UK’s initiative to sequence 100 thousand genomes reached its goal after operating for five years and five months. Whole-genome sequencing was offered to patients…
Novel CRISPR-Cas14 – the smallest CRISPR system discovered
Discovery of new CRISPR (clustered regularly interspaced short repeats) system in archea organisms provides new tool for genetic research. The most popular CRIPSR-Cas9 has many…
Better detection of circulating tumor DNA
A new method, fragment size analysis, has helped to more precisely detect circulating tumor DNA in blood samples. Tumor cells leak some of their DNA…
H3F3A mutations can be detected in bloodstream
Pediatric patients with diffuse midline gliomas have acquired a new tool: non-invasive liquid biopsy detecting essential variantions of H3F3A gene. Histone genes (HIST1H3B/C, HIST2H3C, H3F3A)…